Coordination compounds offer many binding modes to polynucleotides, including outersphere noncovalent binding, metal coordination to nucleobase and phosphate backbone 810 metal complexes as drugs and chemotherapeutic agents. Copperii complexes as potential anticancer and nonsteroidal. The numerous practical applications of copper compounds are discussed, including homogeneous and heterogeneous catalysis and their use as fungicides, pesticides. Under these backgrounds, many copper complexes have been explored to address anticancer therapy and one of them has entered the phase i. Synthesis of dipyridyl ketone isonicotinoyl hydrazone copper. Copper complexes of carboxamidrazone derivatives as. Among nonpt compounds, copper complexes are potentially attractive as anticancer agents.
Human clinical trials continue to evaluate the therapeutic efficacy of copper complexes as anticancer agents and considerable progress has been made in understanding their pharmacological requirements. Copperii complexes as anticancer agents slideshare. Anticancer agents in medicinal chemistry, 2009, 9, 185211 185 copper complexes as anticancer agents cristina marzano1, maura pellei2, francesco. Bhuvanesh,b raju senthil kumarc and aziz kalilur rahiman a. Pt iv complexes, commonly referred to as ptiv prodrugs, are also used as chemotherapeutic agents. All copperi complexes were evaluated for their antiproliferative activity against a panel of human cancer cell. Anticancer activity and computational modeling of ternary. Copperi complexes of phosphines, functionalized phosphines and phosphorus heterocycles is a comprehensive guide to one of the most widely used and extensively studied metals. Synthesis and characterisation of copperii complexes with.
Anticancer drugs, metal ion complex, transition metal compound. Transitionmetal based complexes hold several advantages. Read copper complexes of carboxamidrazone derivatives as anticancer agents. Progress in copper complexes as anticancer agents abstract.
Tetrahedral copperi tpcup complexes 115, where tp is a n,n,ntrisazolylborate and p is a tertiary phosphine, have been synthesized and characterized by means of nmr, esims, and xasexafs, and xray diffraction analyses on the representative complexes 1 and 10, respectively. Copper complexes as anticancer agents bentham science. Validation data supporting the characterization of novel. Mar 27, 2019 the difference in response of tumor cell and normal cell towards copper possibly laid the foundation of copper complexes evolution as anticancer agents. The potential of metalbased anticancer agents has only been fully realized and explored since the landmark. Jan 29, 2019 new cyclams and their copperii and ironiii complexes. In an effort to better understand the biological efficacy of the tridentate aroyl hydrazone cuii complexes, the cuii complex of di2pyridyl ketone isonicotinoyl hydrazone ligand hl, culh2oh2ono3n c1 was synthesized and characterized. Synthesis and characterisation of copperii complexes. The vast array of information available for their bioinorganic properties and mode of action in several biological systems, combined with. Experimental section all commercially obtained reagentgrade chemicals were used without further purification, except for the ligand, which were prepared according to the.
As potential anticancer drugs, there are currently extensively studied mainly complexes of copperii. Finally, the estrogencomplexes are involved in the cellular redox stress by stimulating the production of ros reactive. Special emphasis has been focused on the identification of structureactivity relationships for the different classes of copperi,ii complexes. This selectivity stems from the hypoxic environment of cancer cells that promotes the reduction of cuii to cui, leading a proapoptotic oxidative. Cobaltiii complexes as potential anticancer agents.
Copperi complexes of n24 methoxy2chloro4nitrophenyln. Advances in copper complexes as anticancer agents chemical. Sep 01, 2016 read cobaltiii complexes as potential anticancer agents. Finally, the estrogen complexes are involved in the cellular redox stress by stimulating the production of ros reactive. The vast array of information available for their bioinorganic properties and mode of action in several biological systems, combined with the new. Selected copperi complexes as potential science anticancer. Full text metal complexes in cancer therapy an update. Novel copper complexes as potential proteasome inhibitors for.
Metalbased anticancer drugs are among the most successful therapeutic agents, as evidenced by the frequent prescription of selected platinum and arsenic compounds to patients. Pdf metalbased antitumor drugs play a relevant role in antiblastic chemotherapy. Moreover, up to now, despite the enormous efforts in synthesizing different classes of copper complexes, very few data concerning the molecular basis of the mechanisms underlying their antitumor. Anticancer agents in medicinal chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and uptodate with the latest and most important developments in cancer drug discovery. In vitro and in vivo anticancer activity of copperi. Pdf copper complexes as anticancer agents researchgate. Request pdf progress in copper complexes as anticancer agents the clinical success of cisplatin has stimulated the quest for novel anticancer metallodrugs during the last two decades. The difference in response of tumor cell and normal cell towards copper possibly laid the foundation of copper complexes evolution as anticancer agents. Her research interests include drug design and discovery, medicinal and toxicological chemistry, and molecular and cellular biology. Cisplatin is regarded as one of the most effective drugs, even if severe.
Anticancer activity, dna binding and cell mechanistic. The complexes, which were stable in aqueous solution, showed cytotoxicity that was superior to that of the corresponding parent compound carboplatin, thus suggesting an interesting synergy between the ability of the nitrate. Actually, since many years a lot of researches have actively investigated copper compounds based on the assumption proposal that endogenous metals may be less toxic. Anticancer activity of copper ii complexes with a pyridoxalsemicarbazone ligand 2. Cisplatin is regarded as one of the most effective drugs, even if. View enhanced pdf access article on wiley online library html view. However, a large number of copper complexes with various sets of ligands have been prepared for this cause and displayed noteworthy in vitro cytotoxicities 10 16. Electron sprays ionization mass spectra esi ms the mass spectra of complexes figures s4 and s5 support their projected formulation. Synthesis, crystal structure, in vitro cytotoxicity and dna damage studies. Anticancer potential of metal thiosemicarbazone complexes. Copper displays multiple functions in human organisms, increased copper uptake in cancer cells was verified and copper complexes are prone to redox reactions. Copperii complexes as potential anticancer and nonsteroidal anti.
Pdf copper complexes as anticancer agents carlo santini. Metalbased anticancer agents covers the interdisciplinary world of inorganic drug discovery and development by introducing the most prominent compound classes based on different transition metals, discussing emerging. Copper cu, which is an essential trace element in all living organisms, is important in maintaining the function of numerous proteins and enzymes. The selected bond distances and bond angles are reported in table s1. Synthesis and potential application as anticancer agents. These complexes have some benefits over ptii drugs including, they are stable enough to administered orally versus iv, their stability may diminish the side effects caused by ptii drugs, and they may have higher affinity to structural modification via their axial. Jul 16, 2001 read copper complexes of carboxamidrazone derivatives as anticancer agents. In recent years, the successful development of metalbased pharmaceuticals, including copper anticancer agents, has attracted more attention on metal complexes in cancer treatment. This is an open access article under the cc by license. Anticancer activity, dna binding and cell mechanistic studies.
Viva voce examination university of madras interaction of copperii complexes of bi and tridentate ligands with dna and their antiproliferative effects on osteosarcoma cancer cell s rajalakshmi chemical laboratory. There are only few complexes of copperi in the literature, whereas they also show a very strong cytotoxic activity. Copperi chemistry of phosphines, functionalized phosphines. The fundamental role of copper and the recognition of its complexes as important bioactive compounds in vitro and in vivo aroused an everincreasing interest in these agents as potential drugs for therapeutic intervention in various diseases. There are only few complexes of copper i in the literature, whereas they also show a very strong cytotoxic activity. Metal complexes in cancer therapy an update from drug design perspective umar ndagi, ndumiso mhlongo, mahmoud e soliman molecular modelling and drug design research group, school of health sciences, university of kwazulunatal, westville, durban, south africa abstract. Redouane tabti, nassera tounsi, christian gaiddon, embarek bentouhami and laurent desaubry the clinical success of cisplatin has stimulated the quest for novel anticancer metallodrugs during the last two decades. Article views are the countercompliant sum of full text article downloads since november 2008 both pdf and html across all institutions and individuals. Read cobaltiii complexes as potential anticancer agents. Metalbased antitumor drugs play a relevant role in antiblastic chemotherapy. The cytotoxic effect of all compounds was examined on human cervical cancer hela cells, revealing strong anticancer activity. As a consequence, many of them do not exhibit druglike properties and significant anticancer effects in vivo.
As potential anticancer drugs, there are currently extensively studied mainly complexes of copper ii. Copperii complexes of schiff base ligands as promising. Copper ii complexes as potential anticancer and nonsteroidal antiinflammatory agents. In vitro and in vivo studies skip to main content thank you for visiting. This work was motivated by the observation that no comprehensive surveys of copper complexes as anticancer agents were available in the literature. In the past, metalbased compounds were widely used in the treatment of disease conditions, but the lack of clear. Single crystal xray study reveals that complex c1 forms 1d zigzag chains in solid state. Copperii complexes as potential anticancer and nonsteroidal antiinflammatory agents. Copperii complexes of schiff base ligands as promising anticancer agents 1elzbieta hejchman 1, barbara sowirka1, magdalena tomczyk, dorota maciejewska1 1,department of organic chemistry, faculty of pharmacy, medical university of warsaw, 1 banacha,02 097 warsaw, poland. Anticancer activity of copper ii complexes with a pyridoxal. Under these backgrounds, many copper complexes have been explored to address anticancer therapy and one of them has entered the phase i clinical trial.
New cyclams and their copperii and ironiii complexes. The research on copper i,ii coordination compounds as antiproliferative agents has increased as demonstrated by the high number of papers published in this field in the period 20082012. Request pdf advances in copper complexes as anticancer agents the research on copperi,ii coordination compounds as antiproliferative agents has. Many cytotoxic metal complexes target dna because of its importance in replication and cell viability. Physicochemical, structural, cytotoxic activity and dnaprotein interactions, journal of photochemistry and photobiology b. Platinum complexes containing organic nitrate ligands were investigated as anticancer agents. Synthesis, characterization and crystal structure of cuappccl 2, appcn 1 2acetylpyridinepyridine2carboxamidrazone, inorganica chimica acta on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. One of the major disadvantages associated to these copperii complexes is. Copper i complexes of phosphines, functionalized phosphines and phosphorus heterocycles is a comprehensive guide to one of the most widely used and extensively studied metals. Experimental section all commercially obtained reagentgrade chemicals were used without further purification, except for the ligand, which were prepared according to the previously described procedure37. Nov 15, 2015 copperii complexes as anticancer agents 1. Studies have shown that the copper complexes, such as dithiocarbamate 4,5, 8hydroxyquinoline, clioquinol and some. Oct 26, 2019 this series of cu compounds are potent anticancer agents with low and submicromolar ic 50 values and the cellular uptake follows the lipophilicity order meaning that the internalisation mainly happened via passive diffusion.
This series of cu compounds are potent anticancer agents with low and submicromolar ic 50 values and the cellular uptake follows the lipophilicity order meaning that the internalisation mainly happened via passive diffusion. The search on copper coordination compounds as anticancer agents has boosted dramatically in the last few years. Special emphasis has been focused on the identification of structureactivity relationships for the different classes of copper i,ii complexes. Copperii complexes of schiff base ligands as promising anticancer agents elzbieta hejchman, barbara sowirka, magdalena tomczyk, dorota maciejewska faculty of pharmacy, medical university of warsaw, warsaw, poland. Biology on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. Progress in copper complexes as anticancer agents hilaris. Mar 27, 2019 copper ii complexes as potential anticancer and nonsteroidal antiinflammatory agents. Copper complexes as prospective anticancer agents rsc publishing. Anticancer drugs, metal ion complex, transition metal compound received july 2015 received in revised form 31 july 2015 accepted 2 august 2015 address for correspondence. An insight into cytotoxic mode, authorrais ahmad khan and mohammad usman and rajakumar dhivya and perumalsamy balaji and ali alsalme and hamad al.
The frontier orbitals of homo and lumo of hl, 1, and 2 are also given in figure 2. Copperii complexes bearing nonsteroidal antiinflammatory drugs nsaids are known to potently kill cancer stem cells cscs, a subpopulation of tumour cells with high metastatic and relapse fidelity. Advances in copper complexes as anticancer agents request pdf. Metal complexes have important applications in many aspects of life. Full geometry optimization of hl and copperii complexes 1 and 2 was carried out using density functional theory dft at the b3lyp level in their ground state shown in figure 2. Likewise, new tailormade copper complexes have been designed based on structural and biological features ideal for their anticancer activity. Although phosphine copper complexes appear to be a very promising class of metallodrugs alternative to platinum drugs, few data on their mechanism of action have been reported so far. Heteroleptic copperi complexes of scorpionate bispyrazolyl carboxylate ligand with auxiliary phosphine as potential anticancer agents.
Her recent research has focused on development of novel metalbased drugs in particular, copper complexes acting as anticancer agents. Recent progress on the unique features of nextgeneration targeted metalbased anticancer agents, including supramolecular coordination complexes used for both therapy and drug delivery, promise a bright future beyond the benefits of pure cytotoxic activity. The numerous practical applications of copper compounds are discussed, including homogeneous and heterogeneous catalysis and their use as fungicides, pesticides, pigments for paints, resins and. Although many copper complexes have been proposed as promising. The use of metal complexes in the pharmaceutical industry has recently increased and as a result, novel metal. Viva voce examination university of madras interaction of copper ii complexes of bi and tridentate ligands with dna and their antiproliferative effects on osteosarcoma cancer cell s rajalakshmi chemical laboratory. Furthermore, copperiibased complexes appear to be very promising candidates for anticancer therapy.
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