Jun 30, 2015 although dramatic changes in the delivery of radiation therapy have occurred, the impact of radiobiology on the clinic has been far less substantial. Clinical cancer research impact factor, if, number of article, detailed information and journal factor. Current problems in cancer seeks to promote and disseminate innovative, transformative, and impactful data on patientoriented cancer research and. The natural history of treated gbm remains very poor with 5year survival rates of 5 %. Jul 23, 2019 few previous studies of patients with nonsmall cell lung cancer nsclc and leptomeningeal metastases have used liquid biopsy of cerebrospinal fluid csf to identify epidermal growth factor receptor egfr mutations and guide therapy. Belief was an international, multicentre, singlearm, phase 2 trial done at 29 centres in eight european countries.
Afatinib for advanced nonsmall cell lung cancer in a case. Classifying cancers based on tcell infiltration and pdl1. Clinical breast cancer is a part of elsevier s oncology journal network. Journal citation reports clarivate analytics, 2019.
Journal of experimental and clinical cancer research is ranked in the first quartile of oncology journals in journal citation reports and is the official. Tumour cell secretome in chemoresistance and tumour. The aim of this study was to investigate the impact of number of circulating tumor cells ctcs on the treatment outcome for metastatic gastric cancer gc following palliative chemotherapy. Expression and clinical significance of hypoxiainducible. In terms of research annually, usa, india, japan, brazil and canada are some of the leading countries where maximum. Colon cancer as per available reports about 186 journals, 280 conferences, 48 workshops are presently dedicated exclusively to colon cancer and about 114796 articles are being published on the current trends in colon cancer. Evaluation of mir29c inhibits endotheliocyte migration and angiogenesis of human endothelial cells by suppressing the insulin like growth factor 1. Risk factors, prediction, and prevention from childhood.
A 34yearold male patient with nsclc and leptomeningeal metastases was admitted to the interventional radiology department, tianjin huanhu hospital on 18th. American cancer society colorectal cancer survivorship care. Check out new collections focusing on breast cancer. Journal cancer genetics and cytogenetics impact factor issn. The path to approval of targeted therapy for lung cancers with alterations of the met protooncogene receptor tyrosine kinase met, however, has not been straightforward. Clinical cancer research is especially interested in clinical trials evaluating new treatments for cancer. Impact factor of journal cancer genetics and cytogenetics. Tp53 mutations were evaluated in 123 patients in relation to disease control rate dcr, objective response.
While the standard impact factor measures citations to journal articles published within a 2year period, the 5year impact factor evaluates citations to journal articles published within a 5year period to provide a measure of a journals longerterm influence. It is still the leading cause of morbidity and mortality of women worldwide. Eligible patients were aged 18 years or older and had treatmentnaive, pathologically confirmed stage iiib or stage iv lung adenocarcinoma with a confirmed, activating egfr mutation exon 19 deletion or l858r mutation. To analyze the impact of tp53 mutations on response to firstline tyrosine kinase inhibitors tki in patients with egfrmutated nonsmall cell lung cancer nsclc. Egfrtyrosine kinase inhibitors egfrtkis have achieved remarkable outcomes in the treatment of patients with egfrmutant nonsmallcell lung cancer, but acquired resistance is still the main factor restricting their longterm use. International journal of cancer and clinical research. There are numerous immune cell types found in cancers and many components of an immune reaction to cancer. Each issue of cancer strives to be comprehensive, spanning the breadth of oncology disciplines and providing something for everyone involved in cancer research, risk reduction, treatment, and.
Opportunities and challenges of radiotherapy for treating. If you have any questions or concerns, please reach out to a member of the aacr publishing staff. International journal of cancer and clinical research clinmed. Although her2 protein expression by immunohistochemistry ihc and gene amplification by fluorescence in situ hybridization fish assays are routinely used to select patients to receive trastuzumab, both. The applications of the disciplines of pharmacology, immunology, cell biology, and. Journal impact factor 2015 impact factor list 2015 2014. The past 20 years have seen dramatic changes in the delivery of radiation therapy, but the impact of radiobiology on the clinic has been far less substantial. Updated list of high journal impact factor colon cancer. Clinical breast cancer has a 2018 journal impact factor of 2. An integrated model of care for individuals and couples, 30 oct 2015, south kensington, london, united kingdom.
Current problems in cancer is a part of elseviers oncology journal network. Estimated numbers of new cancer cases for 2015, excluding basal cell and squamous cell skin cancers and in situ carcinomas except urinary bladder. American cancer society colorectal cancer survivorship. Clinical cancer research impact factor 201819 trend. Low levels of basal autophagy prevent the gradual accumulation of damaged proteins and organelles in tissues that is toxic over time. Erlotinib and bevacizumab in patients with advanced nonsmall. A pubmed search from january 1, 1966 to march, 2015 was performed using the key terms ipilimumab, pembrolizumab, lambrolizumab, nivolumab, immune checkpoint inhibitor, mdx010, mdx101, bms734016, mk3475, sch 900475. Understanding how cancer cells overcome chemotherapyinduced cell death is critical in promoting patient survival. The journal encourages to publish original, novel, and welldesigned studies.
Delayed initiation of chemotherapy and breast cancer jama. Aacr journals metrics american association for cancer. Opportunities and challenges of radiotherapy for treating cancer. Nov 21, 2019 egfrtyrosine kinase inhibitors egfrtkis have achieved remarkable outcomes in the treatment of patients with egfrmutant nonsmallcell lung cancer, but acquired resistance is still the main factor restricting their longterm use. Sladek ne et al 2002 cellular levels of aldehyde dehydrogenases aldh1a1 and aldh3a1 as predictors of therapeutic responses to cyclophosphamidebased chemotherapy of breast cancer. A cancer journal for clinicians publishes information about the prevention, early detection, and treatment of cancer, as well as nutrition, palliative care, survivorship, and additional topics of interest related to cancer care. Impact of tp53 mutations on outcome in egfrmutated.
Advances in cancer research rg journal impact rankings 2018. Currently, the best that can be offered is a modest 14month overall median survival in patients undergoing maximum safe resection plus adjuvant. State estimates are offered as a rough guide and should be interpreted with caution. Jul 21, 2015 the development of precision medicine for the management of metastatic breast cancer is an appealing concept. To analyze the impact of tp53 mutations on response to firstline tyrosine kinase inhibitors tki in patients with egfr mutated nonsmall cell lung cancer nsclc. Hif2 complex dissociation, target inhibition, and acquired resistance with pt2385, a firstin. Vascular endothelial growth factor vegf is a protein that strongly promotes angiogenesis and its expression profile correlates with the estrogen receptor status of breast cancer cells adams et al. Apr 15, 2020 check out new collections focusing on breast cancer, immunotherapy, solid tumors, and gastrointestinal cancer. Updated list of high journal impact factor cancer science.
Sarcopenia in an overweight or obese patient is an adverse prognostic factor in pancreatic cancer. Therefore, studying the impact of diet in the development and treatment of cancer should be a clinical priority. The journal changed title to the american journal of cancer in 1931. Clinical cancer research, is a journal of the american association for cancer research whose focus is to. Jul 15, 2019 the journal of cancer research 19161930. Primary care clinicians can access the free ca patient page for crc survivors or download it from the journal. Impact of tp53 mutations on outcome in egfrmutated patients. Frontiers afatinib for advanced nonsmall cell lung cancer. Obesity is a leading contributing factor to cancer development worldwide. Mar 10, 2016 glioblastoma gbm is the most common and lethal tumor of the central nervous system. Table of contents journal of cancer research hindawi. Loss of nuclear localized parathyroid hormonerelated protein in primary breast cancer predicts poor clinical outcome and correlates with suppressed stat5 signaling.
With clinical breast cancer indexed in pubmedmedline, your published article is guaranteed maximum visibility. A pubmed search from january 1, 1966 to march, 2015 was performed using the key terms ipilimumab, pembrolizumab, lambrolizumab, nivolumab, immune checkpoint inhibitor, mdx010, mdx101, bms734016, mk3475, sch 900475, mdx. Tanei t et al 2009 association of breast cancer stem cells identified by aldehyde dehydrogenase 1 expression with resistance to sequential paclitaxel and epirubicinbased chemotherapy for breast cancers. Prospective study evaluating the impact of tissue confirmation of metastatic disease in patients with breast cancer. You did a great service to the cancer research community and by that to the patients that donated the samplesclinical pathologist, karolinska university hospital. In addition to the t790 m mutation of egfr, amplification of the met or cmet gene has long been recognized as an important resistance mechanism for first or. Clinical cancer research rg journal impact rankings 2018 and. Clinical genitourinary cancer is a part of elsevier s oncology journal network. Breast cancer development and metastasis is a multistep process, often.
Breast cancer is the third leading cause of cancer deaths and highest among women aged between 20 and 59 years based on a cancer statistics in 20. Check out new collections focusing on breast cancer, immunotherapy, solid tumors, and gastrointestinal cancer. Clinical cancer research is especially interested in clinical trials evaluating new treatments, accompanied by research on. In 2015, an estimated 231 840 cases of invasive breast cancer were diagnosed in the united states. Epidemiological evidence suggests that diet affects cancer risk and also substantially alters therapeutic outcome. Chemoresistance is a major factor driving tumour relapse and the high rates of cancer related deaths. The journal of cancer research and clinical oncology publishes. Small, localized ptcs accounted for most of the increase, largely reflecting the more widespread use of diagnostic imaging procedures and improvements in. Clinical cancer research impact factor if 201920182017. Read 1100 articles with impact on researchgate, the professional network for scientists.
Deregulation of splicing factors and breast cancer. Impact of met alterations on targeted therapy with egfr. For example, basal autophagy is upregulated in hypoxic tumor regions, where it is essential for. Cancer prevention research impact factor abbreviation. The editorinchief is mauro castelli regina elena national cancer institute. The shiva study1 is the first randomised investigation of precision therapy. Expression of glypican3 gpc3 in malignant and nonmalignant human breast tissues the open cancer journal, 2015, 8. Erlotinib and bevacizumab in patients with advanced non. Chemoresistance is a major factor driving tumour relapse and the high rates of cancerrelated deaths. It is the official journal of the regina elena national cancer institute. Clinical cancer research impact factor 201819 quartile is q1.
Impact of overweight and obesity on us papillary thyroid. Precision medicine for metastatic breast cancerlimitations. We are committed to sharing findings related to covid19 as quickly and safely as possible. Clinical cancer research publishes original articles describing clinical research on the cellular and molecular characterization, prevention, diagnosis, and therapy of human cancer. The journal changed title to cancer research in 1941.
Cancer management and research article processing fees. Overexpression of hypoxiainducible factor 1 alpha indicates diminished response to radiotherapy and unfavorable prognosis in patients receiving radical radiotherapy for cervical cancer. Circulating tumor cells are predictive of poor response to. It has been proposed that four different types of tumor microenvironment exist based on the presence or absence of tumor. A new cdk9 inhibitor on the block to treat hematologic malignancies, clara alcon, et al. Current status and future directions of the immune checkpoint. Forkhead box transcription factor foxo3a mediates the. Aacr cancer progress report 2015 clinical cancer research. Quantification of her family receptors in breast cancer. It was established in 1982 and has been published by biomed central since 2008, when the journal joined biomed central. Advances in cancer research rg journal impact rankings. Glioblastoma gbm is the most common and lethal tumor of the central nervous system. In terms of research annually, usa, india, japan, brazil and canada are some of the leading countries where maximum studies related to proteomics are being carried out.
The clinical success of trastuzumab in breast cancer taught us that appropriate tumor evaluation is mandatory for the correct identification of patients eligible for targeted therapies. Breast cancer is the most common cancer in women worldwide. Download citation style files for your favorite reference manager. Sep 12, 2016 therapeutic options in recurrent glioblastoma an update 12 september 2016 impact factor 0. We will be providing unlimited waivers of publication charges for accepted articles related to covid19. Clinical cancer research impact factor if 201920182017 bioxbio. It has been proposed that four different types of tumor microenvironment exist based on the presence or. Autophagy captures and degrades intracellular components such as proteins and organelles to sustain metabolism and homeostasis. This is likely due to inherent deficiencies in the microenvironment and to the increased metabolic and biosynthetic demands imposed by deregulated proliferation figure 1b and ref. Survival has not significantly improved over the last decades. First discovered in the mid1980s, the hepatocyte growth factor receptor met pathway was found in the 1990s to be dysregulated in lung cancer fig. To provide the clinician with an update and the current status and future direction of approved immune checkpoint inhibitors icis in oncology. First, patients with cancer often have several molecular alterations, and many patients are unlikely to respond to monotherapy. Thus, the tumor has many strategies to evade an immune response.
Therapeutic options in recurrent glioblastoma an update. The effects of treatment on nuclear factorkappab activation, cell cycle. Kobayashi y, togashi y, yatabe y, mizuuchi h, jangchul p, kondo c, et al. Patients received oral erlotinib 150 mg per day and. Journal of cancer research and clinical oncology home springer.
The journal of cancer research and clinical oncology publishes significant and uptodate articles within the fields of experimental and clinical oncology. Updated list of high journal impact factor colon cancer journals. Each issue of cancer strives to be comprehensive, spanning the breadth of oncology disciplines and providing something for everyone involved in. Fcs2015 frontiers in cancer science 2015, 02 nov 2015. Us thyroid cancer incidence rates have increased substantially since the early 1980s, driven largely by an increase in papillary thyroid cancer ptc, the most common histologic type.
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